The whole evidence base, in the order the argument runs.

Fitness Interface

Access to the world is mediated by evolved fitness interfaces, not guaranteed veridicality.

Signal-Default Epistemology

Motivational-emotional outputs are treated as prima facie informative about the organism's regulated conditions, by default. The signal is read as information about input conditions and current state, not as noise to be suppressed. This is a diagnostic default, not a presumption of veridicality (OF1 stands) and not a contraindication to symptom relief where indicated. The default is displaced by positive evidence of decoupling or direct physiological perturbation: developmental miscalibration carried forward, chronic dysregulation, acute organic disease or state shift (sleep deprivation, inflammation, endocrine perturbation, delirium), structural damage, and substance or medication effects.

Inclusive Fitness

Inclusive fitness - survival and reproduction - is the loss function of selection, not of the organism's runtime computation.

Domain-Sensitive Interacting Adaptations

The organism contains evolved, domain-sensitive, interacting functional adaptations.

Systematic Mismatch

Modern environments often push these adaptations outside their expected or regulatable operating ranges.

Defensive Signals Under Mismatch

Many aversive outputs are intelligible defensive signals under mismatch, not evidence of defective design.

Socially Scaffolded Regulation

Human regulation is constitutively socially scaffolded; social context is likely the highest-leverage cross-cutting input dimension.

Recurrent Coupling and Cascading

Systems are recurrently coupled; perturbations propagate and can self-maintain across domains.

Proxy Hijacking via Open Loops

Proxy cues can activate systems without meeting the conditions that normally regulate or terminate them.

Defensive Over-Activation Bias

Defensive systems err toward over-activation under asymmetric error costs.

Competing Motivational Programs

The architecture contains partially competing motivational programs and tradeoff structures.

Developmental Calibration

The architecture calibrates to developmental and ongoing environmental input within evolved ranges.

Phylogenetic Priority

Motivational programs have phylogenetically determined priority relations. Older, survival-critical systems can suppress or commandeer newer systems.

Non-Substitutability of Mechanism Resolution

Mechanism resolution conditions are not fully interchangeable. Improvement in one mechanism can buffer or modulate consequences in another, especially where mechanisms are recurrently coupled (DA3), but cross-system buffering does not generally replace the specific resolution conditions of an impaired mechanism. Well-being is often bottlenecked by severe unresolved deficits in individual mechanisms and is not well described as a simple average across mechanism states.

Heritable Parameter Variation

Architecture parameters (drive gains, thresholds, calibration setpoints) vary between individuals within heritable ranges.

Allostatic Load Accumulation

Chronic unresolved activation accumulates as allostatic load.

Market Proxy Exploitation

Markets can industrialize proxy exploitation of unmet regulatory needs.

Environment as Primary Intervention Layer

Cortical override of subcortical activation is metabolically expensive, and chronic defensive activation downregulates the cortical override machinery itself. Interventions that change the organism's actual input conditions are therefore frequently more durable and less effort-dependent than interventions targeting cognitive override alone. The environment is a primary intervention layer for systemic and population-scale change, and is currently underweighted by major institutions. This does not preclude individual-level cognitive, pharmacological, or psychotherapeutic interventions where indicated; the claim is about default leverage and systemic design, not exclusivity or head-to-head comparative efficacy in individual cases.

Inclusive Fitness as Loss Function

Natural selection operates on inclusive fitness - survival plus reproduction weighted by relatedness - establishing a single loss function that all evolved motivational architecture serves, as demonstrated independently by Darwinian selection theory, Hamilton's kin-selection formalism, and experimental altruistic-punishment findings that humans enforce cooperation at personal cost where inclusive-fitness logic predicts.

Domain-Sensitive Organism Architecture

The human organism contains evolved, domain-sensitive, interacting functional adaptations rather than a general-purpose learner - supported independently by Tooby & Cosmides' design-principle derivation, Panksepp's conserved subcortical affective-motivational systems, and Bowlby's attachment-as-primary-motivational-system framework.

Systematic EEA-Modern Environment Mismatch

Modern post-agricultural, post-industrial environments push evolved adaptations outside their expected operating ranges in systematic and predictable ways - established independently by Eaton & Konner's discordance hypothesis, Li/van Vugt/Colarelli's mismatch-identification framework, Boyd & Richerson's gene-culture coevolution constraint (matched must include cultural scaffolding), and Henrich's WEIRD empirical diagnostic showing Western populations anchor the extreme end of the cross-cultural distribution.

Phylogenetic Conservation of Subcortical Affective Systems

The core affective-motivational systems (SEEKING, FEAR, RAGE, CARE, PANIC/GRIEF, PLAY, LUST) are anatomically and functionally conserved across mammals and extend into birds for specific systems - established independently by Panksepp's deep-brain-stimulation and cross-species neuroscience, Bowlby's attachment cross-mammalian homology, and Hrdy's cross-primate parental/alloparental evidence.

Socially Scaffolded Regulation via Attachment

Human regulation is constitutively socially scaffolded: the organism's default expectation is proximity to trusted co-regulators, and this scaffolding is architectural rather than optional - established independently by Coan's Social Baseline Theory fMRI program, Bowlby's attachment theory, Hrdy's cooperative-breeding thesis, Dunbar's social-brain hypothesis, and Holt-Lunstad's mortality meta-analysis showing 50% survival advantage from strong social relationships.

Wanting-Liking Dissociation as Proxy Hijack

Motivational pursuit ('wanting', mediated by mesolimbic dopamine) is dissociable from hedonic satisfaction ('liking'), creating an open-loop vulnerability where proxy cues can activate the SEEKING system without providing the conditions that normally terminate or resolve it - established independently by Berridge & Robinson's incentive-salience neuroscience, Tinbergen's supernormal-stimuli ethology, and Panksepp's SEEKING-circuit affective neuroscience.

Adverse Experience Cascading Dose-Response

Chronic or developmental adverse experiences cascade across physiological systems in a dose-response manner, with effects that propagate and self-maintain across domains (metabolic, immune, neural, behavioral) - established independently by Felitti's ACE Study clinical epidemiology, McEwen's allostatic-load neuroendocrinology, and Panksepp's cross-system inhibition evidence for affective-system propagation.

Error Management Asymmetry in Defensive Systems

Defensive systems evolved under asymmetric error costs err reliably toward over-activation (false-positive) because the cost of missing a true threat historically exceeded the cost of reacting to a non-threat - established independently by Nesse's smoke-detector principle in evolutionary psychiatry, Haselton & Buss's Error Management Theory in evolutionary social psychology, and the Öhman/Mineka fear-module visual-attention program in cognitive neuroscience.

Allostatic Load Accumulation

Chronic unresolved activation of stress-response systems produces cumulative physiological damage across multiple organ systems (allostatic load), reversible in part by environmental correction - established independently by McEwen's neuroendocrinology of allostasis and allostatic load, Felitti's ACE dose-response clinical epidemiology, and Sapolsky's primate stress physiology linking hierarchy type to cortisol and downstream pathology.

Threat-Detection via Ancient Subcortical Circuits

Threat detection and defensive response are mediated by phylogenetically ancient subcortical circuits (amygdala, periaqueductal gray, hypothalamus) that operate pre-attentively and can override cortical processing - established independently by Panksepp's FEAR-system neuroanatomy, the Öhman/Mineka backward-masking fear-module research program, and Nesse's clinical evolutionary psychiatry linking panic and anxiety to these defensive systems.

Reciprocity, Norm Enforcement, and Coalition Architecture

Humans have specialized architecture for reciprocal exchange, cheater detection, norm enforcement, and coalitional identity - supported independently by Fehr & Gächter's experimental altruistic-punishment findings, Boehm's reverse-dominance coalition dynamics in hunter-gatherer anthropology, and Tomasello's shared-intentionality comparative-cognition research.

Developmental Calibration within Evolved Ranges

Specific physiological and behavioral systems calibrate during specific developmental windows to environmental inputs within evolved parameters; inputs outside those parameters produce persistent miscalibration - established independently by Bowlby's attachment developmental calibration, McEwen's HPA-axis calibration neuroendocrinology, and Felitti's ACE Study dose-response evidence for durable effects of early-life exposure.

Aversive Outputs as Intelligible Defensive Signals

Many aversive psychological and physiological outputs (anxiety, low mood, pain, grief, fatigue, anger) are intelligible defensive signals produced by architecture that is functioning correctly in response to inputs outside its expected operating range - established independently by Nesse's 'good reasons for bad feelings' evolutionary psychiatry, Panksepp's affective neuroscience of conserved aversive systems, and Fehr & Gächter's finding that anger/moralistic outrage is the proximate mechanism for prosocial norm enforcement rather than a dysregulation.

Reproductive Motivation as Distinct Architecture

Reproductive motivation (desire, attraction, pair-bonding) is a distinct architectural system independent of general-purpose pursuit, with sex-differentiated substrates and a characteristic proxy gradient from real partner to pure proxy - established independently by Panksepp's LUST-circuit affective neuroscience, Buss's sexual strategies theory and sex-differentiated mate preferences research, and Haselton/Buss's error-management prediction of sex-differentiated perceptual biases around mating cues.

Heritable Individual Variation in Behavioral Traits

Individual differences in human behavioral and psychological traits are substantially heritable in every adequately measured domain, established independently by twin designs (Polderman et al. 2015 meta-analysis of fifty years of twin studies: 17,804 traits from 2,748 publications, average reported heritability 49%), adoption and family designs (the Plomin program: significant genetic influence on all psychological traits with corroborating adoption evidence), and molecular SNP-heritability estimated from unrelated individuals (the Yang et al. 2010 GCTA line), with Turkheimer's three laws of behavior genetics as the canonical framing. Heritability is a population statistic under a given environment distribution, not individual determinism.

DC2 empirical depth beyond Schüll and Moss

Missing. Dedicated empirical depth on Haugen's Facebook Files and on companion-AI harm. The companion-AI reference (Muldoon & Parke 2025, New Media & Society, DOI 10.1177/14614448251395192) has now been located and catalogued as a work; extractions from it remain to be added in v1.

Why it matters. DC2 (Market Proxy Exploitation) grounds A1 AI alignment and A6 platform regulation. It currently rests on Schüll (gambling) and Moss (food), which is narrow. Companion AI is the highest-risk contemporary case and does not yet have primary-source grounding in Cor.

Current approach. Muldoon & Parke 2025 catalogued and cited in DC2's derivation (resolved 2026-05-29). Deeper empirical grounding (Haugen Facebook Files; further companion-AI studies) remains v1 corpus work.

Matched-state measurement protocol

Missing. Cor specifies resolution conditions per mechanism (for example M3: reliable intimate co-regulators typically ~5+; M10: varied daily movement typically ~9-15km/day; M7: dark-cued sleep onset), but operationalizing 'matched' as a measurable state across all 14 mechanisms - with inter-rater and test-retest reliability - is unfinished.

Why it matters. The measurement-protocol gap limits A4 personal assessment from becoming a validated instrument and blocks quantitative A6 policy evaluation against mechanism resolution conditions.

Current approach. A public-facing tool built on the framework will prototype the measurement protocol for A4 individual-level audits. Formal psychometric validation is independent research downstream of the core framework.

AI alignment matched/mismatched evaluation axis operationalization

Missing. A1 proposes 'matched / mismatched' as a fourth evaluation axis alongside helpful, harmless, and honest. What is missing is a concrete set of test cases - what a 'matched' response to a specific user query looks like versus a 'mismatched' one - scored in a way that a red-team or evaluation harness can apply systematically.

Why it matters. A1's matched/mismatched evaluation proposal is currently a framework, not an evaluation instrument. Without concrete scorable test cases, the matched/mismatched axis is a conceptual contribution to alignment evaluation rather than a working protocol that labs can run against model outputs.

Current approach. A1's evaluation-criteria field carries the resolution-check and proxy-gradient tests as conceptual criteria. Operational red-team-scorable test cases are the next step of the alignment evaluation work.

M14 cross-cultural variation evidence

Missing. M14 is sex-differentiated, with distinct female (VMH-centered) and male (POA-centered) neural architectures carrying different emphasis on commitment cues versus variety cues. Cross-cultural tests of these specific claims are thin, and the ovulatory-shift literature in particular has an active replication debate.

Why it matters. M14 is the most culturally contested mechanism and the one most likely to be challenged on grounds of cultural construction. A weak empirical cross-cultural base makes the mechanism vulnerable to legitimate challenge even though the core neuroarchitecture is well-supported.

Current approach. Haselton/Buss Error Management Theory and Buss sexual strategies work are the current evidence base. Ovulatory-shift-specific claims are explicitly flagged as contested in extraction caveats to preserve the nuance.

M6 human neurobiology replication

Missing. The Maier & Seligman 2016 reformulation of learned helplessness (default passivity with vmPFC-DRN override) is well-supported in rodent models, but the human neurobiological translation - fMRI studies of controllability in humans - is thinner. Karasek's decision-latitude work provides strong human-level evidence but at a different level of analysis.

Why it matters. M6 is critical as a cascade-break point in Cor's applied framework (A2 clinical practice, A3 environment design, A6 work regulation). Strong rodent evidence combined with weaker human-specific neural evidence leaves the mechanism vulnerable to challenge at the human-specificity level.

Current approach. The rodent-level circuit claims are treated as settled; the human-level circuit mapping is treated as well-supported rather than definitively established. The distinction is preserved in the mechanism description.

Bridge Thesis BT1 empirical discriminator

Missing. BT1 (Panksepp-Barrett Resolution) is defended conceptually - subcortical affective circuits are real, and folk emotion categories are constructed overlays on top of them. What is missing is a crisp empirical discriminator test that would adjudicate specific cases where the Panksepp and Barrett frameworks make divergent predictions.

Why it matters. Bridge theses are load-bearing for Cor's epistemic credibility. If a bridge is only conceptually defensible and cannot be tested against a concrete prediction, critics can characterize the resolution as rhetorical rather than substantive.

Current approach. BT1 is presented as a level-of-analysis distinction: Panksepp's cross-species deep-brain-stimulation results ground the primary-process claim; Barrett's cross-cultural folk-category variation grounds the tertiary-process claim. The discriminator gap is explicitly acknowledged in the bridge-thesis narrative.

Cultural-matched vs ancestrally-matched distinction

Missing. Boyd & Richerson's gene-culture coevolution constraint requires that 'matched' include cultural scaffolding, not just ancestral surface forms. But operationalizing which cultural configurations count as matched versus mismatched requires a criterion that does not collapse into either ancestral essentialism (only hunter-gatherer life counts) or cultural relativism (everything counts).

Why it matters. Without this distinction sharpened, P3 (Systematic Mismatch) can be attacked as either too permissive (all cultures are matched by definition) or too restrictive (only hunter-gatherer configurations count).

Current approach. The constraint is treated as 'matched must lie within the envelope of culturally-scaffolded human variation historically observed.' The criterion is acknowledged to be not fully sharp and flagged for sharper operationalization in future theoretical work.

M14 proxy gradient clinical validation

Missing. The five-level M14 proxy gradient (real partner → attenuated real → partial proxy → pure proxy soft → pure proxy hard) is architecturally derived but lacks clinical validation metrics. Which clinical presentations map to which proxy level, and what are the dose-response clinical consequences of sustained use at each level, remain open questions.

Why it matters. A1 AI alignment risk analysis and A2 clinical practice both depend on being able to locate specific proxy products on the gradient with some reliability.

Current approach. The gradient is used as a theoretical organizing device. Clinical validation is flagged as a priority research program for A2 clinical applications.

Convergence coverage for 10 of 15 mechanisms

Missing. Cor's forcing-convergence layer currently covers 5 of 15 mechanisms (M1, M2, M3, M11, M14) with explicit multi-literature convergences. The remaining 10 mechanisms (M4, M5, M6, M7, M8, M9, M10, M12, M13, R1) have supporting extractions populating their evidence junctions but do not yet have explicit convergence rows forcing them from multi-stream replication.

Why it matters. Convergences are the forcing-set level of Cor's evidence pyramid. A mechanism without an explicit convergence is an admission that the evidence does not yet force it from multi-stream convergence, even when Tier-1 status is warranted on single-literature grounds.

Current approach. The original convergence pass followed a strict rule (≥3 independent literatures each). A follow-up convergence pass should be able to add convergences for M6 (Maier/Seligman + Karasek + Amat/Baratta), M7 (Walker + Roenneberg + Czeisler), M12 (Rozin + Curtis + Schaller), and possibly M10 (Pontzer/Lieberman + Chekroud large-cohort + Schuch meta-analysis).

Challenge layer depth

Missing. The current challenge layer holds 5 challenge extractions (EAAT philosophical critique, social-media-effect-size meta-analyses, Landy disgust-moral meta-analysis). Dedicated challenges from Active Inference (Friston) as a competing framework, substance-specific addiction neuroscience (Volkow/Kreek), and cultural-construction critiques of specific mechanism claims beyond Barrett are not yet in the corpus.

Why it matters. A credible framework must engage its strongest critics. The current challenge layer is thin and leans on methodological critiques rather than framework-level competitors like Active Inference or RDoC.

Current approach. The current challenge layer is treated as sufficient for initial framing. A dedicated challenge-layer expansion is a priority for the next round of work, covering Active Inference, addiction neuroscience, and RDoC comparisons.

v2_extractions evidence_quality schema narrowing

Missing. The current evidence_quality categories compress some distinctions that matter for specific epistemic claims - cross-species biological replications, landmark longitudinal cohorts, ethnographic evidence from non-WEIRD populations, and contested findings each carry different epistemic weight but can currently collapse into broader buckets such as 'replicated' or 'clinical'.

Why it matters. Cross-species replication is especially load-bearing for Cor's phylogenetic-priority claims (DA8, ancient affective circuits). Longitudinal cohort depth matters for ACE-dose-response claims. Contested findings should be first-class flaggable to surface scope questions to readers drilling into primary evidence.

Current approach. The broader buckets are used as the machine-readable tag; finer-grained epistemic nuance is preserved in the caveats field per row. Expansion of the first-class tag list is under review.

Restorative Environments domain primary-source grounding

Missing. The new Restorative Environments domain has no primary extractions yet. A primary-source ingestion queue is defined, each item to be grabbed under v2 standards (full text, fresh extraction, verbatim author_quote, DOI/PMID or physical collection) and never ingested via a review: (1) Ulrich 1984, "View through a window may influence recovery from surgery," Science, the anchor stress-recovery result; (2) Kaplan and Kaplan 1989, The Experience of Nature (Attention Restoration Theory), with Berman, Jonides and Kaplan 2008, Psychological Science, as the experimental test; (3) Miyazaki and Li forest-medicine primaries on phytoncides, NK-cell activity, and cortisol/HRV (strongest primary studies, not review-of-reviews); (4) Hartig et al. 2014, "Nature and health," Annual Review of Public Health, itself a review, so treat as a routing source only under the same rule as the Yong review; (5) Bratman et al. 2015, PNAS, nature walk reduces rumination and subgenual prefrontal activity, a strong mechanism-level primary.

Why it matters. Restorative-environment mismatch is the cleanest non-social mismatch available to Cor: strong evidence, an obvious resolution condition, and a delivery form that need not be literal wilderness. It makes the atlas visibly more than a social-mismatch account. Until the primaries are extracted, the domain is a container without grounding.

Current approach. Domain created as a cross-cutting input-resolution domain with no new mechanism. Evidence-tagging discipline recorded in the domain description (stress-recovery and attention-restoration core well-supported and partly replicated; forest-medicine immune findings thinner and often small-sample, so tag down when in doubt). Queue to be worked as future v2 extraction work.

Social-mismatch competition: candidate convergence versus downstream expression

Missing. Yong, Lim, Tan and Chan 2026 (DOI 10.3390/bs16050650) advance a "social evolutionary mismatch and competition hypothesis": social features of mismatch (increasing population size, fragmented communities, rising socioeconomic inequality, constant exposure to inflated social-status cues) jointly inflate real and perceived competition, driving obsessive status pursuit, hostility, risk appetite, ultralow fertility, and social withdrawal (tang ping, quiet quitting, hikikomori). Open question: is this a distinct convergence Cor is currently missing, or a downstream expression of existing structure, namely C9 (Allostatic Load Accumulation) plus C11 (Reciprocity, Norm Enforcement, and Coalition Architecture) plus M5 status and rank regulation and DC2 market proxy exploitation?

Why it matters. It is the one original theoretical move in an otherwise routing-only review, and it bears directly on whether Cor's convergence layer is complete. Resolving it either surfaces a genuine gap in the forcing-set layer or sharpens the claim that competition intensification is already entailed by existing convergences and mechanisms.

Current approach. Logged as an open derivation question, not added to the locked convergence inventory. Evaluate the theoretical spine first: Sng, Neuberg and Kenrick 2017 (resource competition and life-history, density-dependent life-history strategy) as candidate mechanism-level grounding, then test whether the Yong competition construct reduces to C9 plus C11 plus M5 plus DC2 or requires its own forcing convergence.

Tier 3 regulatory-input candidates beyond R1

Missing. R1 (Touch) is currently the only Tier 3 regulatory input in the inventory. Other candidate regulatory inputs deserve architectural consideration: thermoregulation signaling to M2/M6, gut-brain axis signaling to M3/M8, hydration signaling, and proprioceptive/vestibular input regulation.

Why it matters. R1's inclusion establishes the Tier 3 category - but leaving it as a set of one invites scope questions about why touch and not other regulatory inputs are architecturally load-bearing.

Current approach. R1 is treated as the template for the Tier 3 category. Additional regulatory inputs are candidates for future architectural work but are not added retroactively without explicit review.

Phase 8 provenance mis-classification risk

Missing. Some extractions imported from prior cleanup passes may be mis-classified at the source_type level - for example, an extraction marked as 'primary' research that on closer reading of the source paper turns out to be a propagation of another researcher's finding through a later author's lens.

Why it matters. The primary/propagation distinction is important for citation-chain auditability - readers tracing an evidence claim back to its source should land on the original research, not a secondary interpretation. Mis-classification creates downstream drift in this chain.

Current approach. Imported source_type labels are trusted pending a content-level audit against the original source papers. Rows where a discrepancy is suspected are flagged for review.

Joint-authorship FK limitation on v2_works

Missing. Jointly-authored works are currently credited to a single primary researcher in the database, with co-authors listed only in the free-text authors field. For example, The Adapted Mind is credited to Tooby but also co-authored by Cosmides; Not by Genes Alone is credited to Boyd but also co-authored by Richerson; Paleolithic Nutrition to Eaton and Konner; The Mismatch Hypothesis to Li, van Vugt, and Colarelli.

Why it matters. Researcher-coverage queries against the primary-researcher field undercount jointly-authored contributors. Cosmides, Richerson, Konner, and van Vugt each show zero distinct work rows under this query even though they are substantive co-authors of pillar works.

Current approach. Joint authorship is handled via the free-text authors field. A dedicated author-join table is a candidate future improvement if per-author granular queries become necessary.

Agency and Controllability

Learned helplessness research (Maier & Seligman reformulation), decision latitude, vmPFC-DRN circuitry, and the agency-as-override-of-default-passivity framework. Maps to M6; critical cascade-break point for A2 clinical work.

Alloparenting and Distributed Care

Hrdy's cooperative-breeding thesis, parental-burnout research, the alloparental-network requirement, and the consequences of nuclear-family isolation for child development and parent wellbeing. Maps to M9; relevant to A3, A4, A5.

Allostatic Load

Research on cumulative physiological cost of chronic activation: McEwen's allostasis framework, Whitehall socioeconomic-gradient work, Felitti ACE dose-response, Sapolsky primate hierarchy-cortisol links. Grounds DC1. Critical for A6 policy and A2 clinical.

Attachment and Social Bonding

Attachment theory, co-regulation research, grief, loneliness epidemiology, and the social-baseline literature. Maps to M3; primary domain for DA2 evidence and for A2, A3, A4, A5 applications.

Bridge Thesis Research

Research areas where seemingly conflicting frameworks admit a level-of-analysis resolution - notably the Panksepp-Barrett debate on emotion natural kinds vs constructed emotions. Grounds BT1.

Cascade Dynamics

Cross-mechanism cascade research: depression cascades, anxiety-insomnia spirals, social isolation cascades, sickness behavior traps, status-defeat cascades, parent burnout, proxy hijacking spirals, and reproductive disruption cascades. Grounds DA3 (cascading) and DA8 (phylogenetic priority). Central for A2 clinical reasoning about which lever to pull first.

Contamination and Behavioral Immunity

Three-domain disgust research (Rozin), behavioral immune system (Schaller, Curtis), pathogen-prevalence cross-cultural psychology, and the moral/social extensions of contamination avoidance. Maps to M12.

Cooperation and Alliance

Reciprocal altruism research, norm enforcement, altruistic punishment (Fehr & Gächter), reverse dominance (Boehm), and shared intentionality (Tomasello). Maps to M11; grounds social-contract claims in A6 policy.

Defensive Signals and Symptom Reframing

Research on aversive psychological and physiological outputs as intelligible defensive signals rather than malfunctions - Nesse evolutionary psychiatry, Birkett & Newton-Fisher captive-chimp abnormality, Bowlby environment of evolutionary adaptedness. Grounds DA1. Directly reframes A2 clinical practice.

Developmental Calibration

Research on developmental windows in which specific systems calibrate to environmental inputs within evolved parameters - attachment (Bowlby), HPA axis (Meaney), adolescent circadian shift (Walker), Bucharest early-intervention studies. Grounds DA7. Supports A2 clinical, A5 education.

Energy Regulation and Diet

Satiety signaling research, constrained energy expenditure, ultra-processed food effects, and the dietary-intervention trials (SMILES, HELFIMED). Maps to M13; grounds A6 food policy work.

Inflammation and Immune Regulation

Sickness behavior research, cytokine signaling, inflammation-depression links, and the cascading role of chronic low-grade inflammation. Maps to M8; key hub for DA3 cascading and A2 clinical rethinking.

Mismatch Architecture

The mismatch hypothesis literature proper - Eaton & Konner discordance, Li/van Vugt/Colarelli mismatch review, Boyd & Richerson gene-culture coevolution, Henrich WEIRD psychology. Grounds P3. Central to the whole framework and all applications.

Movement and Regulatory Physiology

Exercise-as-regulator research, Pontzer's constrained-energy model, movement-as-zeitgeber, and the anti-inflammatory and mood-regulatory effects of embedded daily movement. Maps to M10; supports A2 clinical, A3 environment design, A6 policy.

Play and Social Calibration

Rough-and-tumble play research, developmental play deprivation, play circuits, and the education-policy consequences of structured-activity substitution. Maps to M4; critical domain for A5 education application.

Proxy Exploitation

Research on how industrial proxies (variable-reward apps, ultra-processed food, pornography, AI companions, social-media status metrics) hijack evolved mechanisms by supplying input cues without resolution conditions. Grounds DA4 (open-loop vulnerability) and DC2 (market exploitation). Central to A1 AI alignment and A6 platform regulation.

Pursuit and Exploration

SEEKING-system research on goal pursuit, reward, engagement, motivation, and the open-loop vulnerabilities that variable-reward applications and proxy cues exploit. Maps to M2; central to DC2 and DA4 application analysis.

Reproductive Motivation

Sexual strategies theory, sex-differentiated mate preferences, pair bonding research, LUST circuit neuroscience, and the proxy gradient from real partner to pure proxy. Maps to M14; central to A1 AI alignment risk-pattern analysis.

Restorative Environments

Restricted contact with natural and restorative environments as an input mismatch. Framed resolution-condition-first, not form-first: the target is the functional restorative property (fractal visual complexity, soft-fascination attention recovery, non-threatening biological motion, restorative soundscape, phytoncide exposure), not "return to nature" and not an innate biophilia drive. Forest exposure is one delivery form; built and urban environments can supply the same properties, which keeps the domain scalable and out of the naturalistic-fallacy trap. Classified cross-cutting because restorative input resolves several existing systems rather than one: threat and vigilance de-arousal with parasympathetic recovery (Ulrich Stress Reduction Theory), directed-attention restoration (Kaplan Attention Restoration Theory), allostatic offloading (DC1 and C9), immune and inflammatory modulation (M8; forest-medicine phytoncide and NK-cell work), and reduced rumination (Bratman). No new mechanism is asserted; nature contact is treated as an environmental input that lets existing systems stand down, consistent with the core thesis that the fix is the environment. Evidence discipline: the stress-recovery and attention-restoration core is well-supported and partly replicated; forest-medicine immune findings are thinner and often small-sample, so tag down at extraction time. Primary-source grounding is pending (see the ingestion-queue gap, G15). Note: the biophilia literature is the umbrella term for this territory, but Cor treats it as an input-resolution domain, not an innate-drive claim.

Sleep and Circadian Regulation

SCN master clock research, chronotype variation, social jetlag, sleep deprivation consequences, and chronotherapy in psychiatric conditions. Maps to M7; large evidence base and central to A2 clinical and A3 environment design.

Status and Rank Regulation

Hierarchy physiology, rank vigilance, shame and submission, Whitehall-style socioeconomic gradient research, and the status-defeat cascade. Maps to M5; central to the DC2 platform-regulation case.

Threat Management

Research and applied work on defensive responses to threat cues: fear circuitry, frustration-aggression, panic disorder, PTSD, and the conditions under which safety can be established. Maps to M1; feeds A2 clinical and A3 environment design applications.

Touch and C-Tactile Input

C-tactile afferent research (McGlone), skin-to-skin contact trials (Feldman, Charpak kangaroo care), and touch as a regulatory input to M3 rather than a standalone motivational system. Maps to R1.

Darwin's "Horrid" Doubt Revisited: A Critical Reassessment of Evolutionary Arguments against Truth

Maurizio Esposito, 2025

Screens, Teens, and Psychological Well-Being: Evidence From Three Time-Use-Diary Studies.

Orben A, Przybylski AK, 2019

A meta-analysis of the association between adolescent social media use and depressive symptoms.

Ivie EJ, Pettitt A, Moses LJ, Allen NB, 2020

Social Media Use and Internalizing Symptoms in Clinical and Community Adolescent Samples: A Systematic Review and Meta-Analysis.

Fassi L, Thomas K, Parry DA, Leyland-Craggs A, Ford TJ, Orben A, 2024

Does Incidental Disgust Amplify Moral Judgment? A Meta-Analytic Review of Experimental Evidence

Landy JF, Goodwin GP, 2015

Resolving the paradox of common, harmful, heritable mental disorders: Which evolutionary genetic models work best?

Keller, M. C., & Miller, G. F., 2006

Resolving the paradox of common, harmful, heritable mental disorders: Which evolutionary genetic models work best?

Keller, M. C., & Miller, G. F., 2006

'Dunbar's number' deconstructed

Lindenfors P, Wartel A, Lind J, 2021

Depression as sickness behavior? A test of the host defense hypothesis in a high pathogen population

Stieglitz J, Trumble BC, Thompson ME, Blackwell AD, Kaplan H, Gurven M, 2015

Functional disability and social conflict increase risk of depression in older adulthood among Bolivian forager-farmers

Stieglitz J, Schniter E, von Rueden C, Kaplan H, Gurven M, 2015